Abstract: Climate change is increasingly affecting rural areas worldwide. The Lower Mekong Basin (LMB) is at particular risk due to heat stress, changing rainfall patterns, rising sea levels, and more frequent and extreme climatic events. It is imperative that local-level adaptation plans are developed in a manner that builds resilience to these growing threats. Strategies for developing adaptation plans tend to comprise predominantly science-led or predominantly community-led processes. This study examines an approach that balances inputs from both processes in characterizing community vulnerability as a component of the adaptation planning workflow. Evaluation sites are located within four distinct sub-regions of the LMB: the Vietnam Mekong Delta, the Annamite Mountains of Lao PDR, the Cambodia central lowlands, and the mid-elevation forests of northern Thailand. Our results indicate that by merging science-based data with community-level perspective, knowledge gaps from both sides are filled and a more comprehensive understanding of vulnerability is factored into adaptation planning.